Different cancer types behave in different ways (Picture: Getty/Science Photo Libra) Scientists have identified how a specific substance plays a key role in helping prostate cancer to spread and become harder to treat. They hope the findings might offer new treatment options for aggressive prostate cancer. A team at Nottingham Trent University found that ‘transglutaminase 2’ (TG2), which is abundant in many of the body’s cells, is responsible for driving a process which leads to the progression and spreading of the disease. In the UK, prostate cancer is the most common cancer in men – with more than 52,000 diagnosed every year. Early prostate cancer cells require the male hormone androgen to grow. However they can become androgen-independent and therefore harder to treat with current therapies, as they advance. Researchers suggest that until now it has not been clear how that process occurs. ‘This finding has opened a significant pathway for understanding other ...